March 1, 1976Circulation ResearchOpen Access

Changes in cyclic nucleotide levels and contractile force in the isolated hypoxic rat heart during perfusion with glucagon.

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Why the study?

Does glucagon perfusion improve recovery of contractile force in isolated hypoxic rat hearts?

Population

Isolated rat hearts

Comparison

Perfusion with hormonal concentrations of… vs Untreated hearts (perfused without glucagon)

Design

Preclinical

Follow-up

3 minutes of hypoxia and 5 minutes of reoxygenation

Authors

RBR W Busuttil RPR J PaddockPrincess of Wales Hospital JFJ. W. FisherTulane University

Discussion

Member takes

Implication

Glucagon may aid post-hypoxic recovery in rat hearts; hypothesis-generating and leaves open clinical translation.

Structured PICO

Does glucagon perfusion improve recovery of contractile force in isolated hypoxic rat hearts?

Population

Isolated rat hearts

Intervention

Perfusion with hormonal concentrations of glucagon during hypoxic perfusion

Comparator

Untreated hearts (perfused without glucagon)

Outcome

Recovery of contractile force during reoxygenationsurrogate

Hormonal concentrations of glucagon exert a protective effect on the hypoxic rat heart, improving contractile recovery and modulating cyclic GMP accumulation.

Cite This Study

Busuttil et al. (1976) studied this question.

synapsesocial.com/papers/6a7789d4c5ab23c76cecb82b https://doi.org/10.1161/01.res.38.3.162

View Full Paper

Ask AI

Bookmark

Changes in cyclic nucleotide levels and contractile force in the isolated hypoxic rat heart during perfusion with glucagon.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Changes in cyclic nucleotide levels and contractile force in the isolated hypoxic rat heart during perfusion with glucagon.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider