Why the study?
Does glucagon alter glycogenolysis and fuel utilization in the isolated perfused rat heart?
Population
Isolated perfused rat heart
Design
Preclinical
Follow-up
5 minutes
Authors
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Supports glucagon-driven glycogenolysis and fuel oxidation in isolated hearts; leaves open relevance to intact human myocardium.
Does glucagon alter glycogenolysis and fuel utilization in the isolated perfused rat heart?
Glucagon stimulates glucose and acetate utilization and rapid glycogenolysis in the isolated rat heart, similar to the effects of epinephrine, likely secondary to increased cardiac work.
Kreisberg et al. (1964) studied this question.
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