January 1, 1988Archives Internationales de Physiologie et de Biochimie
Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart
Why the study?
Does glucagon alter energy-metabolite transport and utilization in the isolated rabbit heart?
Population
Isolated rabbit heart
Comparison
Glucagon (1.5 microM) vs Control/baseline (paired-tracer dilution method)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not inform clinical practice; hypothesis-generating for glucagon effects on cardiac substrate transport in vivo.
Structured PICO
Does glucagon alter energy-metabolite transport and utilization in the isolated rabbit heart?
P
Population
Isolated rabbit heart
I
Intervention
Glucagon (1.5 microM)
C
Comparator
Control/baseline (paired-tracer dilution method)
O
Outcome
Energy-metabolite transport into cardiac muscle (influx of palmitate, D-glucose uptake, utilization of short-chain monocarboxylic acids)surrogate
Glucagon regulates sarcolemmal permeability and myocardial utilization of energy-metabolites from the coronary circulation in the isolated rabbit heart.
Cite This Study
Zloković et al. (1988) studied this question.