Effects of Glucagon on Myocardial Metabolism in Patients With and Without Coronary Artery Disease
Why the study?
Does glucagon administration alter myocardial metabolism in patients with and without coronary artery disease?
Population
Subjects with and without coronary artery disease
Comparison
Glucagon administration vs Baseline and subjects with normal coronary…
Design
Other
Follow-up
5 minutes after administration
Authors
Discussion
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Implication
May support metabolic effects of glucagon in CAD; hypothesis-generating and should not change practice pending larger studies.
Structured PICO
Does glucagon administration alter myocardial metabolism in patients with and without coronary artery disease?
P
Population
Subjects with and without coronary artery disease (including at least 18 patients with significant coronary artery disease)
I
Intervention
Glucagon administration
C
Comparator
Baseline (before glucagon administration) and subjects with normal coronary arteries
O
Outcome
Myocardial metabolism (including arterial glucose level, glucose uptake, myocardial oxygen extraction, and myocardial extraction ratio of lactate)surrogate
Glucagon administration improves aerobic lactate utilization and cardiac efficiency in patients with significant coronary artery disease.
Cite This Study
Bourassa et al. (1970) studied this question.