Key result
Late sodium current dysregulation, primarily involving defects in the Nav1.5 channel encoded by SCN5A, is a causal factor in the development of cardiac arrhythmias.
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Rationale for late INa inhibition in arrhythmias; leaves open prospective validation before practice change.
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Unudurthi et al. (2016) studied this question. Late sodium current dysregulation, primarily involving defects in the Nav1.5 channel encoded by SCN5A, is a causal factor in the development of cardiac arrhythmias.
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