Key result
Atrial fibrillation upon admission was associated with an increased risk of cognitive impairment in patients with ischemic stroke (OR 1.6; 95% CI 1.03-2.47; P = .03).
Why the study?
Does atrial fibrillation predict cognitive impairment in patients with ischemic stroke?
Observational (n=707)
No
Does atrial fibrillation predict cognitive impairment in patients with ischemic stroke?
Odds Ratio: 1.6 (95% CI 1.03–2.47)
p-value: p=.03
Atrial fibrillation upon admission is independently associated with an increased risk of cognitive impairment in patients recovering from ischemic stroke.
AF on admission associated with cognitive impairment after ischemic stroke; hypothesis-generating for trials on AF-specific interventions.
BACKGROUND: Atrial fibrillation (AF) is considered as a risk factor for cognitive impairment. METHODS: This retrospective chart review study was conducted in a patient stroke rehabilitation ward of a university-affiliated referral hospital. The participants were 707 patients admitted for a standard rehabilitation course after an ischemic stroke. Cognitive status was assessed by the Mini-Mental State Examination (MMSE), and scores lower than 24 points were considered as suggestive of cognitive impairment. RESULTS: Atrial fibrillation, age, gender, diabetes, and dementia emerged as the only statistically significant parameters differing between those with MMSE score lower than 24 or higher. In a multiple logistic regression analysis, AF (odds ratio 1.6, 95% confidence interval 1.03-2.47, P = .03) was associated with an increased risk of cognitive impairment. CONCLUSIONS: Our findings suggest that atrial fibrillation upon admission is independently associated with lower MMSE scores in patients with ischemic stroke.
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Mizrahi et al. (2011) conducted an observational in Ischemic stroke (n=707). Atrial fibrillation vs. No atrial fibrillation was evaluated on Cognitive impairment (MMSE score < 24) (OR 1.6, 95% CI 1.03-2.47, p=.03). Atrial fibrillation upon admission was associated with an increased risk of cognitive impairment in patients with ischemic stroke (OR 1.6; 95% CI 1.03-2.47; P = .03).
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