What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Atrial fibrillation and cognitive function (n=952). Intervention: Atrial fibrillation vs. No atrial fibrillation. Primary outcome: Composite cognitive z score (p=0.0003).

What question did this study set out to answer?

This study aims to determine the association between atrial fibrillation and cognitive function in elderly men, considering previous strokes and other risk factors.

September 1, 1998Stroke

Atrial Fibrillation Is an Independent Determinant of Low Cognitive Function

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Key result

Atrial fibrillation was associated with lower mean adjusted cognitive z scores (-0.26 vs +0.14; P=0.0003) in elderly men, independent of stroke, high blood pressure, and diabetes.

Why the study?

Is atrial fibrillation associated with low cognitive function in elderly men?

Population

952 community-living men, aged 69 to 75 years, in Uppsala, Sweden

Comparison

Atrial fibrillation vs No atrial fibrillation

Design

Cross-sectional

Authors

LKLena KilanderUppsala University BABertil AndrénUppsala University HNHåkan NymanKarolinska University Hospital

Discussion

Member takes

Implication

AF may warrant cognitive screening in elderly men; leaves open causality and whether AF treatment alters decline.

Key Points

This study aims to determine the association between atrial fibrillation and cognitive function in elderly men, considering previous strokes and other risk factors.
Cross-sectional study involving 952 community-living men aged 69 to 75 years in Uppsala, Sweden.
Cognitive functions assessed using Mini-Mental State Examination and Trail Making Tests to calculate a composite z score.
Analyses adjusted for age, education, occupational level, and other vascular risk factors.
Men with atrial fibrillation (n=44) had lower mean cognitive z scores (-0.26 +/- 0.11) compared to those without it (+0.14 +/- 0.03; P=0.0003).
In men without previous strokes, those with atrial fibrillation (n=36) still showed lower cognitive scores (-0.24 +/- 0.12 vs. +0.17 +/- 0.03; P=0.0004).
Treated men with atrial fibrillation (n=27) had better cognitive scores (-0.05 +/- 0.21) than untreated men (n=9; -1.14 +/- 0.34; adjusted P=0.0005).

Study Design

Type

Cross-Sectional (n=952)

Multicenter

Structured PICO

Is atrial fibrillation associated with low cognitive function in elderly men?

Population

952 community-living men aged 69 to 75 years in Sweden, evaluated for the association between atrial fibrillation and cognitive function.

Exposure

Atrial fibrillation

Comparator

No atrial fibrillation

Outcome

Cognitive function (composite z score calculated from Mini-Mental State Examination and Trail Making Tests)surrogate

Main Result

Absolute Event Rate: -0.26% vs 0.14%

p-value: p=0.0003

Atrial fibrillation is independently associated with lower cognitive function in elderly men, even in the absence of manifest stroke.

Cite This Study

Kilander et al. (1998) conducted a cross-sectional in Atrial fibrillation and cognitive function (n=952). Atrial fibrillation vs. No atrial fibrillation was evaluated on Composite cognitive z score (p=0.0003). Atrial fibrillation was associated with lower mean adjusted cognitive z scores (-0.26 vs +0.14; P=0.0003) in elderly men, independent of stroke, high blood pressure, and diabetes.

synapsesocial.com/papers/6a5c187de505a3be3956face https://doi.org/10.1161/01.str.29.9.1816

Topics

Persistent AF management Atrial fibrillation Anticoagulation in AF

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Atrial Fibrillation Is an Independent Determinant of Low Cognitive Function

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Atrial Fibrillation Is an Independent Determinant of Low Cognitive Function

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider