Atrial fibrillation and cognitive decline
Why the study?
Does incident atrial fibrillation increase the rate of cognitive decline in older adults without clinical stroke?
Population
5,150 men and women aged 65 years and older from the community-based Cardiovascular Health Study, without…
Comparison
Incident atrial fibrillation vs No prior atrial fibrillation
Design
Cohort
Follow-up
mean 7 years
Authors
Discussion
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Member takes
Implication
Incident AF was associated with accelerated cognitive decline without stroke; leaves open whether rhythm control or anticoagulation alters trajectories in older adults.
Structured PICO
Does incident atrial fibrillation increase the rate of cognitive decline in older adults without clinical stroke?
P
Population
5,150 men and women aged 65 years and older from the community-based Cardiovascular Health Study, without atrial fibrillation or history of stroke at baseline.
I
Intervention
Incident atrial fibrillation
C
Comparator
No prior atrial fibrillation
O
Outcome
Rate of decline in mean scores on the 100-point Modified Mini-Mental State Examination (3MSE)surrogate
Incident atrial fibrillation is associated with accelerated cognitive decline in older adults, even in the absence of clinical stroke.
Cite This Study
Thacker et al. (2013) studied this question.