Key result
Individuals with overlap syndrome (COPD and OSA) had greater carotid artery stiffness and lower executive function-processing speed compared to those with either disorder alone.
Why the study?
Previous studies showed greater carotid artery stiffness and lower cognitive function in COPD alone and OSA alone, but their combined impact in overlap syndrome had not been demonstrated.
Does overlap syndrome (COPD and OSA) worsen carotid artery stiffness and cognitive function compared to either condition alone?
Cross-Sectional
Does overlap syndrome (COPD and OSA) worsen carotid artery stiffness and cognitive function compared to either condition alone?
Overlap syndrome (COPD and OSA) is associated with greater carotid artery stiffness and lower cognitive function than either condition alone, suggesting a synergistic detrimental effect on vascular and cognitive health.
Overlap syndrome may warrant closer cognitive monitoring; extends single-disease data but leaves causality open.
Previous studies have demonstrated greater carotid artery stiffness and lower cognitive function among individuals with COPD alone and OSA alone. However, the present study is the first to demonstrate that individuals that have both COPD and OSA (i.e., overlap syndrome) have greater carotid artery stiffness and lower executive function-processing speed than individuals with either disorder alone. Furthermore, among individuals with overlap syndrome greater carotid artery stiffness is associated with lower executive function-processing speed.
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Luehrs et al. (2021) conducted a cross-sectional in Overlap syndrome (COPD and OSA). Overlap syndrome vs. COPD alone or OSA alone was evaluated on Carotid artery stiffness and executive function-processing speed. Individuals with overlap syndrome (COPD and OSA) had greater carotid artery stiffness and lower executive function-processing speed compared to those with either disorder alone.
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