Key result
Metformin attenuated right ventricular remodeling in adult male mice via a mechanism independent of cardiac AMPK.
Why the study?
Right ventricular function predicts survival in age-related disease, but the mechanisms of right ventricular failure remain unclear.
Answers are grounded in this paper and cite their sources.
Metformin may attenuate RV remodeling age- and sex-specifically independent of cardiac AMPK; hypothesis-generating for human RV therapies.
Right ventricular (RV) function predicts survival in age-related disease, yet mechanisms of RV failure are unclear. We show that aged mice undergo exacerbated RV remodeling compared with young. We tested the AMPK activator metformin to improve RV function and show that metformin attenuates RV remodeling only in adult male mice via a mechanism that does not require cardiac AMPK. Metformin is therapeutic for RV dysfunction in an age- and sex-specific manner independent of cardiac AMPK.
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McNair et al. (2023) studied Pulmonary hypertension-induced right ventricular dysfunction. Metformin was evaluated on Right ventricular remodeling and function. Metformin attenuated right ventricular remodeling in adult male mice via a mechanism independent of cardiac AMPK.
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