Why the study?
Are circulating levels of apolipoprotein A1, apolipoprotein B, and their ratio associated with kidney function and chronic kidney disease in the general population?
Population
17,315 individuals from two multiethnic population samples, with a prospective follow-up cohort of 1,659…
Comparison
Serum apolipoprotein A1, apolipoprotein B, and… vs Lower quartiles of apolipoproteins (Q1)
Design
Cohort
Follow-up
10 years (for prospective analysis)
Key result
Higher serum apolipoprotein A1 was associated with a lower prevalence of CKD (Q4 vs Q1 OR 0.73 in ARIC, OR 0.53 in NHANES III) and higher eGFR in two large multiethnic population samples.
Authors
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Higher ApoA1 may support kidney health in observational data; leaves open causality and should not yet change practice.
Observational (n=17,315)
Yes
Are circulating levels of apolipoprotein A1, apolipoprotein B, and their ratio associated with kidney function and chronic kidney disease in the general population?
Odds Ratio: 0.73
p-value: p=0.02
Higher serum apolipoprotein A1 is associated with a lower prevalence of CKD and higher eGFR, whereas apolipoprotein B shows no consistent associations.
Goek et al. (2012) conducted an observational in Chronic kidney disease (n=17,315). Apolipoprotein A1 and B vs. Lower quartiles (Q1) was evaluated on CKD (eGFR<60 mL/min/1.73 m2) (OR 0.73, p=0.02). Higher serum apolipoprotein A1 was associated with a lower prevalence of CKD (Q4 vs Q1 OR 0.73 in ARIC, OR 0.53 in NHANES III) and higher eGFR in two large multiethnic population samples.
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