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December 4, 1991JAMA

Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration

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Authors

FFF. Facchini

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Overview

Cross-sectional study shows insulin resistance decreases urinary uric acid clearance in healthy adults, indicating renal regulation links metabolic resistance to elevated serum uric acid.

Key Points

  • To determine whether insulin-mediated glucose disposal is directly related to serum uric acid concentrations and urinary uric acid clearance.
  • Cross-sectional study evaluated 36 healthy, nondiabetic volunteers without a history of gout at the Stanford University General Clinical Research Center.
  • Measured insulin-mediated glucose disposal, glucose and insulin responses to a 75-g oral glucose load, urinary uric acid clearance, blood pressure, lipid profiles, and body fat distribution.
  • Insulin resistance correlated positively with serum uric acid concentration (r = .69; P < .001), persisting after adjusting for age, sex, and obesity measures (r = .57; P < .001).
  • Urinary uric acid clearance correlated inversely with both insulin resistance (r = -.49; P < .002) and serum uric acid concentration (r = -.61; P < .001).

Cite This Study

F. Facchini (1991) studied this question.

synapsesocial.com/papers/6a7794ce3da069e66cbdb43ahttps://doi.org/10.1001/jama.266.21.3008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship Between Resistance to Insulin-Mediated Glucose Uptake, Urinary Uric Acid Clearance, and Plasma Uric Acid Concentration1991 · 874 citations
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  3. 3#673 Predictive value of insulin resistance and GFR-adjusted uricemia on all-cause mortality: the URRAH study2024
  4. 4Uric acid is associated with features of insulin resistance syndrome in obese children at prepubertal stage.2010 · 35 citations
  5. 5Association between higher estimated glucose disposal rate and reduced prevalence of hyperuricemia and gout2025