Key result
After eccentric exercises, IL-6 expression increased in the cytoplasm of myofibers, peaking at 12 hours and preceding myofiber disruption.
Population
Eccentric contraction model in skeletal muscles
Comparison
Eccentric exercise induced by electrical… vs Baseline/time course comparison
Design
Preclinical
Follow-up
Up to 7 days
Authors
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IL-6 may mark early eccentric muscle damage in animals; leaves open any human diagnostic or therapeutic role.
IL-6 expression increases in myofibers preceding their disruption after eccentric exercise, suggesting a close relationship with strenuous exercise-induced muscle damage.
Tomiya et al. (2004) studied Muscle damage after eccentric exercise. Eccentric exercise (electrical stimulation model) was evaluated on Cell types expressing IL-6 and subcellular compartmentalization over time. After eccentric exercises, IL-6 expression increased in the cytoplasm of myofibers, peaking at 12 hours and preceding myofiber disruption.
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