Key result
Renal denervation for resistant hypertension lacks solid evidence of efficacy and safety, as highlighted by the failure of Symplicity HTN-3 and highly variable blood pressure responses.
Why the study?
Does catheter-based renal denervation reduce blood pressure in patients with resistant hypertension?
Population
Patients with resistant hypertension
Comparison
Catheter-based endovascular sympathetic renal… vs Medical treatment only or sham procedure
Design
Editorial
Authors
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Cautions against routine renal denervation for resistant hypertension outside trials; leaves open its role pending rigorous RCTs.
Does catheter-based renal denervation reduce blood pressure in patients with resistant hypertension?
This editorial strongly cautions against the widespread adoption of renal denervation for resistant hypertension, citing weak evidence, methodological flaws in early trials, and potential safety concerns.
Persu et al. (2014) conducted an editorial in Resistant hypertension. Renal denervation was evaluated. Renal denervation for resistant hypertension lacks solid evidence of efficacy and safety, as highlighted by the failure of Symplicity HTN-3 and highly variable blood pressure responses.
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