Key result
Complete reperfusion after a single thrombectomy pass was associated with higher odds of favorable clinical outcome compared to multiple passes (62% vs 36%; OR 2.4; 95% CI 1.1-4.8; P=0.010).
Why the study?
A true first-pass effect, defined as improved clinical outcome after complete reperfusion with one versus multiple thrombectomy passes in stroke patients, had not yet been specifically addressed.
Does complete reperfusion after a single thrombectomy pass improve clinical outcome compared to multiple passes in stroke patients with anterior circulation occlusions?
Population
164 consecutive anterior circulation stroke patients with known onset and mTICI 3 reperfusion
Comparison
Single thrombectomy pass vs multiple thrombectomy passes
Design
Cohort study with matched-cohort and case-control analyses
Authors
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First-pass mTICI 3 may confer benefit in stroke thrombectomy; leaves open whether pass number independently predicts outcome.
Cohort (n=164)
Does complete reperfusion after a single thrombectomy pass improve clinical outcome compared to multiple passes in stroke patients with anterior circulation occlusions?
Odds Ratio: 2.4 (95% CI 1.1–4.8)
Absolute Event Rate: 62% vs 36%
p-value: p=0.010
Achieving complete reperfusion in a single thrombectomy pass significantly improves the odds of a favorable clinical outcome in stroke patients compared to requiring multiple passes.
Nikoubashman et al. (2019) conducted a cohort in Stroke with anterior circulation occlusion (n=164). Complete reperfusion after a single thrombectomy pass vs. Complete reperfusion after multiple thrombectomy passes was evaluated on Favorable clinical outcome (modified Rankin Scale score, 0-2) (OR 2.4, 95% CI 1.1-4.8, p=0.010). Complete reperfusion after a single thrombectomy pass was associated with higher odds of favorable clinical outcome compared to multiple passes (62% vs 36%; OR 2.4; 95% CI 1.1-4.8; P=0.010).
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