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Summarize the molecular mechanisms, regulatory signaling cascades, and genetic dynamics governing cell adhesion, flocculation, and biofilm development across pathogenic and industrial yeasts.

February 16, 2006Molecular MicrobiologyOpen Access

Flocculation, adhesion and biofilm formation in yeasts

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Authors

KVKevin J. VerstrepenUniversity of Nottingham FKFrans M. KlisUniversity of North Carolina at Chapel Hill

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Implication

Mechanistic review uncovers regulatory pathways and genetic plasticity driving adhesin expression in yeasts, highlighting mechanisms of biofilm formation and industrial flocculation.

Key Points

Summarize the molecular mechanisms, regulatory signaling cascades, and genetic dynamics governing cell adhesion, flocculation, and biofilm development across pathogenic and industrial yeasts.
Reviewed genetic and biochemical evidence detailing cell wall adhesin function across yeast species, notably Saccharomyces cerevisiae, Candida albicans, and Candida glabrata.
Synthesized molecular pathways regulating adhesin expression, including environmental signaling cascades, epigenetic gene silencing, and tandem repeat-driven recombination.
Cellular adhesion is mediated by specific cell wall adhesin proteins governed by the Ras/cAMP/PKA and MAP kinase filamentous growth cascades in response to nutrient deprivation, environmental stress, and host signals.
Phenotypic plasticity is driven by subtelomeric epigenetic switching that yields stochastic adhesin expression and internal tandem repeats that promote recombination, generating novel functional adhesins.

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Verstrepen et al. (2006) studied this question.

synapsesocial.com/papers/6a77984bf6b553d308ae9b0e https://doi.org/10.1111/j.1365-2958.2006.05072.x

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Implication

Mechanistic review uncovers regulatory pathways and genetic plasticity driving adhesin expression in yeasts, highlighting mechanisms of biofilm formation and industrial flocculation.

Flocculation, adhesion and biofilm formation in yeasts

Discussion

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Implication

Key Points

Cite This Study

Flocculation, adhesion and biofilm formation in yeasts

Discussion

Member takes

Implication

Key Points

Cite This Study

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