Key result
Newly diagnosed hypertension was associated with a significantly higher risk of abnormally prolonged QTc interval compared to known hypertension (OR 3.70), with additional risks observed from coexisting diabetes and smoking.
Why the study?
Do disease duration, antihypertensive monotherapy, and coexisting risk factors affect the QTc interval in young hypertensive patients?
Case-Control (n=142)
No
Do disease duration, antihypertensive monotherapy, and coexisting risk factors affect the QTc interval in young hypertensive patients?
Odds Ratio: 3.7 (95% CI 1.16–11.86)
p-value: p=0.03
Young hypertensive patients, particularly those newly diagnosed or with coexisting risk factors like diabetes and smoking, exhibit a high prevalence of prolonged QTc intervals, underscoring the potential value of early ECG screening.
OBJECTIVES: To study the effect of disease duration, treatment and risk factors on QTc interval among young hypertensives. MATERIALS AND METHODS: A case-control study was conducted on 142 hypertensives (60 males, 82 females) taking calcium channel blocker (CCB) or angiotensin-converting enzyme inhibitor (ACEI) as monotherapy. After blood pressure measurement, we recorded lead II electrocardiograph with minimum ten waveforms. QTc was derived from average of ten values using Bazett's formula. QTc interval >0.43 s in male and >0.45 s in female was considered abnormal. Known hypertensives did not differ significantly in QTc values by the duration of disease. CCB users showed small, insignificant disadvantage for abnormally prolonged QTc values than ACEI users. With coexisting diabetes, smoking, and positive family history of hypertension, there was odds risk of 7.69, 2.75, and 2.54, respectively for prolonged QTc. CONCLUSION: Our study showed prolonged QTc in hypertensives more so in newly diagnosed, unaffected by duration or use of ACEI, or CCB but associated with modifiable risk factors. This underscores high risk of repolarization abnormality-induced future events, suggesting early screening of hypertension, strict blood pressure control, optimum use of QTc measurement, and preventive pharmacotherapy to reduce this aftermath.
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Solanki et al. (2016) conducted a case-control in Hypertension (n=142). Newly diagnosed hypertension (<6 months) vs. Known hypertension (>1 year) was evaluated on Abnormally prolonged QTc interval (OR 3.70, 95% CI 1.16-11.86, p=0.03). Newly diagnosed hypertension was associated with a significantly higher risk of abnormally prolonged QTc interval compared to known hypertension (OR 3.70), with additional risks observed from coexisting diabetes and smoking.
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