Key result
Protein kinase C isozymes play critical roles in specific aspects of cardiac remodelling and dysfunction in heart failure.
Population
Patients with heart failure and experimental models of heart failure
Design
Review
Authors
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Cautions against premature PKC-targeted therapy in heart failure; leaves open isoform-specific efficacy for prospective trials.
This review highlights the role of Protein kinase C (PKC) isozymes in cardiac remodeling and their potential as therapeutic targets in heart failure.
Palaniyandi et al. (2008) conducted a review in Heart failure. Protein kinase C (PKC) isozymes was evaluated. Protein kinase C isozymes play critical roles in specific aspects of cardiac remodelling and dysfunction in heart failure.
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