Key result
Levosimendan infusion in patients with nonischemic dilated cardiomyopathy significantly increased strain and strain rate values for both ventricles, NYHA functional class, and left ventricular EF (P<.05).
Why the study?
Does levosimendan infusion improve STE-derived strain and strain rate in patients with nonischemic dilated cardiomyopathy?
Observational (n=22)
Does levosimendan infusion improve STE-derived strain and strain rate in patients with nonischemic dilated cardiomyopathy?
p-value: p=<.05
Levosimendan infusion improves biventricular strain and strain rate, as well as LVEF and NYHA class, in patients with decompensated nonischemic dilated cardiomyopathy.
May improve biventricular strain in advanced nonischemic DCM; hypothesis-generating for STE-guided levosimendan use.
OBJECTIVE: To investigate whether repetitive measurements of speckle tracking echocardiography (STE)-derived strain (S) and strain rate (SR) could reveal changes in left ventricular function in patients with nonischemic dilated cardiomyopathy treated with levosimendan. METHODS: We included 22 consecutive patients (age 53 ±12 years) with an ejection fraction (EF) below 35% and New York Heart Association (NYHA) class III-IV symptoms that required intravenous inotropic support despite optimal medical therapy. The absence of any occlusive coronary artery disease was identified via previous coronary angiography in all patients. Echocardiographic variables, including strain/strain rate, and NYHA functional class, were evaluated before and after levosimendan infusion at the 72nd hour and one month. RESULTS: The strain and strain rate values for both left and right ventricles were observed to be increased NYHA functional class and left ventricular EF (P <.05). CONCLUSION: STE can successfully completed conventional echocardiography in the evaluation of patients with decompensated heart failure who were treated with levosimendan.
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Kırış et al. (2018) conducted an observational in nonischemic dilated cardiomyopathy (n=22). Levosimendan vs. Baseline (before infusion) was evaluated on Strain and strain rate values for both left and right ventricles, NYHA functional class, and left ventricular EF (p=<.05). Levosimendan infusion in patients with nonischemic dilated cardiomyopathy significantly increased strain and strain rate values for both ventricles, NYHA functional class, and left ventricular EF (P<.05).
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