Key result
Calcium sensitizing drugs like pimobendan and levosimendan improve mortality in heart failure by increasing cardiac contractility, but their overall clinical performance remains disappointing.
Population
Patients with acute heart failure (AHF) or congestive heart failure
Design
Review
Authors
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May warrant caution with current calcium sensitizers; leaves open pursuit of more specific agents in heart failure.
This review highlights the limitations and adverse effects of current inotropic and calcium-sensitizing drugs in heart failure, emphasizing the need for novel, more specific calcium sensitizers.
Mohammad Asif (2014) conducted a review in Congestive Heart Failure. Ionotropic Calcium Sensitizing Drugs was evaluated. Calcium sensitizing drugs like pimobendan and levosimendan improve mortality in heart failure by increasing cardiac contractility, but their overall clinical performance remains disappointing.
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