Why the study?
Do calcium sensitizers improve myocardial performance without increasing intracellular calcium load and associated adverse effects in patients with heart failure?
Population
Patients with cardiac failure
Design
Review
Authors
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May support safer inotropy in heart failure; leaves open efficacy on outcomes pending randomized trials.
Do calcium sensitizers improve myocardial performance without increasing intracellular calcium load and associated adverse effects in patients with heart failure?
Calcium sensitizers represent a class of inotropic drugs that improve myocardial performance without increasing intracellular calcium load, potentially avoiding the fatal arrhythmias and increased oxygen consumption associated with traditional inotropes.
Lehmann et al. (2003) studied this question.
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