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March 1, 1986Archives of Internal Medicine

American College of Chest Physicians and the National Heart, Lung, and Blood Institute National Conference on Antithrombotic Therapy

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Population

Patients with cardiovascular disorders including venous thromboembolism, unstable angina, aortocoronary…

Design

Guideline

Authors

JDJames E. DalenGeneral Cardiology

Discussion

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Implication

Supports antithrombotic use in VTE, unstable angina, bypass shunt thrombosis, and TIA; confirms RCT efficacy while leaving other indications open.

Key Points

  • To review the clinical efficacy of antithrombotic therapy across major cardiovascular disorders and address the widespread lack of consensus regarding treatment indications.
  • Synthesized findings from published randomized controlled trials and clinical case series across diverse cardiovascular indications.
  • Convened an expert panel sponsored by the American College of Chest Physicians and the National Heart, Lung, and Blood Institute to develop clinical management consensus.
  • Randomized trial evidence demonstrates clear therapeutic efficacy for antithrombotic therapy in the prevention and treatment of venous thromboembolism, management of unstable angina, prevention of shunt thrombosis after aortocoronary bypass surgery, and treatment of transient cerebral ischemia.
  • Definitive clinical trial evidence remains lacking for several other common cardiovascular indications, resulting in persistent clinical uncertainty and an absence of professional consensus.

Structured PICO

P
Population
Patients with cardiovascular disorders including venous thromboembolism, unstable angina, aortocoronary bypass surgery, and transient cerebral ischemia
I
Intervention
Antithrombotic therapy

The ACCP and NHLBI National Conference on Antithrombotic Therapy aims to provide consensus on the appropriate use of antithrombotic therapy across various cardiovascular disorders.

Cite This Study

James E. Dalen (1986) studied this question.

synapsesocial.com/papers/6a779b6a33def31403ae19b0https://doi.org/10.1001/archinte.1986.00360150060007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antithrombotic Therapy1995 · 42 citations
  2. 2The Use of Antithrombotic Therapies in the Prevention and Treatment of Arterial and Venous Thrombosis2010 · 27 citations
  3. 3Review of the Fifth American College of Chest Physicians Consensus Conference on Antithrombotic Therapy: outpatient management for adults1999 · 32 citations
  4. 4Antithrombotic therapy in cardilogy—systemical improvement of the standard of care for patient population to personalized medicine—2023
  5. 5Balancing Hemostasis And Thrombosis In Interventional Vascular Medicine And Surgery2011