Key result
Transplantation of cardiac progenitor cell sheets onto infarcted rat myocardium increased capillary density (194 vs 97 per mm2, P<0.05) and preserved cardiac contractile function.
Why the study?
Does transplantation of cardiac progenitor cell sheets improve cardiac function and promote cardiogenesis in rats with myocardial infarction?
Population
Rats with myocardial infarction induced by coronary artery ligation
Comparison
Transplantation of scaffold-free cell sheets… vs Untreated myocardial infarction
Design
Preclinical
Follow-up
3 weeks
Authors
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Hypothesis-generating for cell-sheet therapy post-MI; leaves open translation to human trials.
Does transplantation of cardiac progenitor cell sheets improve cardiac function and promote cardiogenesis in rats with myocardial infarction?
Absolute Event Rate: 194% vs 97%
p-value: p=< 0.05
Transplantation of cardiac progenitor cell sheets onto infarcted myocardium in rats promotes neovascularization and cardiomyogenesis, leading to preserved cardiac function.
Zakharova et al. (2010) studied myocardial infarction. cardiac progenitor cell sheet vs. untreated MI was evaluated on capillary density (per mm2) (p=< 0.05). Transplantation of cardiac progenitor cell sheets onto infarcted rat myocardium increased capillary density (194 vs 97 per mm2, P<0.05) and preserved cardiac contractile function.
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