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May 12, 2011Cardiovascular Research

Epicardial adipose stem cell sheets results in greater post-infarction survival than intramyocardial injections

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Key result

Epicardial delivery of adipose-derived stromal cell sheets resulted in a significantly higher survival rate than intramyocardial cell injections (73% vs. 41%, P=0.01) in rats with chronic MI.

Why the study?

Does epicardial delivery of ADSC sheets improve survival and left ventricular remodeling compared to intramyocardial injection in a rat model of chronic myocardial infarction?

Population

82 rats with chronic myocardial infarction and simultaneous harvest of fat tissue to yield adipose-derived…

Comparison

Epicardial deposit of a trilayered autologous… vs Intramyocardial injections of either control…

Design

Preclinical, Randomized 1 month after infarction, Blindly assessed

Follow-up

2 months

Authors

HHHaïfa HamdiUniversité Paris-SudVPValérie Planat‐BenardCentre National de la Recherche ScientifiqueABAlain BelAssistance Publique – Hôpitaux de Paris

Discussion

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Implication

Caution against clinical use of epicardial ADSC sheets; extends preclinical delivery data but leaves human translation open.

Study Design

Type

RCT (n=82)

Blinding

Assessor-blind

Randomization

randomized

Structured PICO

Does epicardial delivery of ADSC sheets improve survival and left ventricular remodeling compared to intramyocardial injection in a rat model of chronic myocardial infarction?

P
Population
82 rats with chronic myocardial infarction randomized 1 month after infarction to receive control medium, ADSC injections, or ADSC sheets, followed for 2 months.
I
Intervention
Epicardial deposit of a trilayered autologous ADSC sheet (10 × 10^6 cells) onto the infarcted area.
C
Comparator
Intramyocardial injections of either control medium (n=24) or 10 × 10^6 autologous ADSCs (n=37).
O
Outcome
Survival, left ventricular function (end-diastolic volume), and cell engraftment assessed at 2 months.hard clinical

Main Result

Absolute Event Rate: 73% vs 41%

p-value: p=0.01

Epicardial delivery of adipose-derived stromal cell sheets improves survival and preserves left ventricular geometry better than intramyocardial cell injections in a rat model of chronic myocardial infarction.

Cite This Study

Hamdi et al. (2011) conducted an RCT in chronic myocardial infarction (n=82). Epicardial deposit of a trilayered ADSC sheet vs. Intramyocardial injections of autologous ADSC or control medium was evaluated on Survival rate (p=0.01). Epicardial delivery of adipose-derived stromal cell sheets resulted in a significantly higher survival rate than intramyocardial cell injections (73% vs. 41%, P=0.01) in rats with chronic MI.

synapsesocial.com/papers/6a9cb0fdc42eb00825f7c0aahttps://doi.org/10.1093/cvr/cvr099
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Also Consider

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  1. 1Release of biomarkers of myocardial damage after direct intramyocardial injection of genes and stem cells via the percutaneous transluminal route2008 · 38 citations
  2. 2Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice2003 · 188 citations
  3. 3Rat Adipose Tissue-Derived Stem Cells Transplantation Attenuates Cardiac Dysfunction Post Infarction and Biopolymers Enhance Cell Retention2010 · 120 citations
  4. 4Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction2007 · 392 citations
  5. 5Transplantation of Adipose Derived Stromal Cells is Associated with Functional Improvement in a Rat Model of Chronic Myocardial Infarction2008 · 219 citations