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October 13, 2007European Heart JournalOpen Access

Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction

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Why the study?

Does intracoronary administration of autologous adipose tissue-derived stem cells improve cardiac function and perfusion in a porcine acute myocardial infarction model?

Population

Porcine acute myocardial infarction/reperfusion model

Comparison

Intracoronary injection of 2 million cultured… vs Intracoronary carrier administration alone

Design

Preclinical

Follow-up

28 +/- 3 days (4 weeks)

Authors

CVChristian ValinaInterventional CardiologyKPKai PinkernellMedigene (Germany)YSYao‐Hua SongSoochow University

Discussion

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Implication

May inform stem cell therapy development in AMI; leaves open translation to human trials.

Structured PICO

Does intracoronary administration of autologous adipose tissue-derived stem cells improve cardiac function and perfusion in a porcine acute myocardial infarction model?

P
Population
Porcine acute myocardial infarction/reperfusion model (induced by inflating an angioplasty balloon for 180 min in the mid-left anterior descending artery)
I
Intervention
Intracoronary injection of 2 million cultured autologous adipose tissue-derived stem cells (ADSCs) or bone marrow-derived stem cells (BMSCs) via balloon catheter
C
Comparator
Intracoronary carrier administration alone
O
Outcome
Cardiac function (left ventricular ejection fraction) and perfusion defect at 28 +/- 3 dayssurrogate

Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular ejection fraction, perfusion, and remodeling in a porcine model of acute myocardial infarction.

Cite This Study

Valina et al. (2007) studied this question.

synapsesocial.com/papers/6a827cdcf2e4e6540e2a5b99https://doi.org/10.1093/eurheartj/ehm426
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