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August 10, 2010PLoS ONEOpen Access

Rat Adipose Tissue-Derived Stem Cells Transplantation Attenuates Cardiac Dysfunction Post Infarction and Biopolymers Enhance Cell Retention

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Why the study?

Does intramyocardial injection of adipose tissue-derived stem cells with biopolymers improve cell retention and cardiac function in a rat model of myocardial infarction?

Population

Rat model of myocardial infarction (isogenic Lewis rats)

Comparison

Intramyocardial injection of 99mTc-labeled… vs ASCs injected with culture medium, non-treated…

Design

Preclinical

Follow-up

4 weeks

Authors

MDMaria Elena DanovizUniversity of WashingtonJNJuliana Sanajotti NakamutaNovartis (Switzerland)FMFábio Luiz Navarro MarquesUniversidade de São Paulo

Discussion

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Implication

Biopolymer co-injection may enhance ASC retention and function in rodent MI; leaves open clinical translation of augmented cell therapy.

Structured PICO

Does intramyocardial injection of adipose tissue-derived stem cells with biopolymers improve cell retention and cardiac function in a rat model of myocardial infarction?

P
Population
Rat model of myocardial infarction (isogenic Lewis rats)
I
Intervention
Intramyocardial injection of 99mTc-labeled adipose tissue-derived stem cells (ASCs, 1x10^6 cells) using fibrin (ASC/F) or collagen (ASC/C) as vehicle, administered 24 hours post-MI
C
Comparator
ASCs injected with culture medium (ASC/M), non-treated (NT) group, and control groups receiving culture medium, fibrin, or collagen alone
O
Outcome
Cell cardiac retention at 24 hours, ventricular morphometry, and direct cardiac functional parameters at 4 weeks post-MIsurrogate

Co-injection of adipose tissue-derived stem cells with biopolymers (fibrin or collagen) significantly enhances cell retention and preserves ventricular function post-myocardial infarction in a rat model.

Cite This Study

Danoviz et al. (2010) studied this question.

synapsesocial.com/papers/6a8bb2ecf71b672e3df48ebahttps://doi.org/10.1371/journal.pone.0012077
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Also Consider

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  1. 1Dynamics and mediators of acute graft attrition after myoblast transplantation to the heart2004 · 174 citations
  2. 2Myocardial infarct size and ventricular function in rats.1979 · 1,283 citations
  3. 3Challenges in Using Stem Cells for Cardiac Repair2010 · 108 citations
  4. 4Preparation of Ready‐to‐use, Stockable and Reconstituted Collagen2005 · 83 citations
  5. 5Adipose Tissue-Derived Stem Cells2009 · 156 citations