May 16, 1988Quarterly Journal of Experimental PhysiologyOpen Access

Effect of Lidocaine on Action Potentials, Currents and Contractions in the Absence and Presence of Ouabain in Guinea‐pig Ventricular Cells

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Population

Guinea-pig ventricular cells

Design

Preclinical

Authors

MMMary R. MitchellUniversity of Aberdeen SPS. PlantSaarland University

Discussion

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Implication

Lidocaine lacks direct SR calcium effects in guinea-pig myocytes; leaves open alternative antiarrhythmic mechanisms in human ventricular cells.

Structured PICO

Population

Guinea-pig ventricular cells

Intervention

Lidocaine (low/therapeutic doses and >500 microM) in the absence and presence of ouabain

Outcome

Electrical and contractile activity (action potential duration, contraction, transient depolarizations, transient inward currents)surrogate

In guinea-pig ventricular cells, lidocaine does not directly affect calcium-induced calcium release from the sarcoplasmic reticulum or indirectly inhibit arrhythmic activity by reducing intracellular sodium.

Cite This Study

Mitchell et al. (1988) studied this question.

synapsesocial.com/papers/6a779f60f6749a0058ec69a8 https://doi.org/10.1113/expphysiol.1988.sp003154

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Implication

Lidocaine lacks direct SR calcium effects in guinea-pig myocytes; leaves open alternative antiarrhythmic mechanisms in human ventricular cells.

Effect of Lidocaine on Action Potentials, Currents and Contractions in the Absence and Presence of Ouabain in Guinea‐pig Ventricular Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Lidocaine on Action Potentials, Currents and Contractions in the Absence and Presence of Ouabain in Guinea‐pig Ventricular Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider