Why the study?
Does the transfer of IgG and/or lymphocytes from rabbits immunized with beta1-adrenoceptor peptide induce myocardial damage in SCID mice?
Population
35 CB-17 severe combined immunodeficiency (SCID) mice
Comparison
Intraperitoneal injection of 2 mg of IgG and/or… vs Intraperitoneal injection of IgG and/or PBL from…
Design
Preclinical
Follow-up
70 days
Authors
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Indicates potential autoimmune myocardial injury; leaves open relevance to human dilated cardiomyopathy.
Does the transfer of IgG and/or lymphocytes from rabbits immunized with beta1-adrenoceptor peptide induce myocardial damage in SCID mice?
Transfer of IgG and lymphocytes from beta1-peptide immunized rabbits induces early myocardial damage in SCID mice, supporting an autoimmune pathogenesis for dilated cardiomyopathy.
Matsui et al. (2003) studied this question.
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