Key result
A concurrent increase in both lactate and procalcitonin levels between days 1 and 2 superseded cytokine measurements and clinical severity scores as the sole independent predictor of 28-day mortality.
Why the study?
Do serial measurements of lactate, procalcitonin, and NT-proBNP improve prognostication of 28-day mortality compared to cytokine measurements and clinical severity scores in patients with septic shock?
Observational (n=72)
Do serial measurements of lactate, procalcitonin, and NT-proBNP improve prognostication of 28-day mortality compared to cytokine measurements and clinical severity scores in patients with septic shock?
Serial measurements of lactate and procalcitonin between days 1 and 2 offer superior prognostic utility for 28-day mortality in septic shock compared to baseline absolute levels, cytokines, or clinical severity scores.
No takes yet. Share an insight, caveat, or question.
May refine septic shock mortality prediction; leaves open prospective validation against cytokines and scores.
Phua et al. (2008) conducted an observational in Septic shock (n=72). Serial lactate and procalcitonin measurements vs. Cytokine measurements and clinical severity scores (APACHE II, SOFA) was evaluated on 28-day mortality. A concurrent increase in both lactate and procalcitonin levels between days 1 and 2 superseded cytokine measurements and clinical severity scores as the sole independent predictor of 28-day mortality.
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