Omeprazole, Hypergastrinemia, and Gastric Carcinoid Tumors

Editorials1 August 1994Omeprazole, Hypergastrinemia, and Gastric Carcinoid TumorsJames W. Freston, MD, PhDJames W. Freston, MD, PhDUniversity of Connecticut Health Center; Farmington, CT 06030Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-3-199408010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The long-term management of reflux esophagitis is challenging because of the frequency of symptomatic relapses and the uncertain efficacy and safety of long-term treatment with acid-suppressing drugs. Reflux esophagitis recurs within 6 months in at least 80% of patients after discontinuation of medical therapy [1]. Thus, some patients, such as those described in this issue by Klinkenberg-Knol and colleagues [2], require continuous therapy with omeprazole. Despite its superior efficacy when compared with histamine-2-(H2) receptor antagonists in healing reflux esophagitis [3] and maintaining remissions [4], clinicians have generally been reluctant to treat patients chronically with omeprazole because of concerns about the ...References1. Hetzel DJ, Dent J, Reed WD, Narielvala FM, Mackinnon M, McCarthy JH, et al. Healing and relapse of severe peptic esophagitis after treatment with omeprazole. Gastroenterology. 1988; 95:903-12. Google Scholar2. Klinkenberg-Knol EC, Festen HP, Jansen JB, Lamers CB, Nelis F, Snel P, et al. Efficacy and safety of long-term treatment with omeprazole for refractory reflux esophagitis. Ann Intern Med. 1994; 121:161-7. Google Scholar3. Maton PN. Omeprazole. N Engl J Med. 1991; 324:965-75. Google Scholar4. Lundell L, Backman L, Ekstrom P, Enander LK, Falkmer S, Fausa O, et al. Prevention of relapse of reflux esophagitis after endoscopic healing: the efficacy and safety of omeprazole compared with ranitidine. 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Argyrophil cell hyperplasia associated with chronic corpus gastritis in gastric ulcer disease. Scand J Gastroenterol. 1991; 26(Suppl 186):90-4. Google Scholar20. Freston JW. Clinical significance of hypergastrinaemia: relevance to gastrin monitoring during omeprazole therapy. Digestion. 1992; 51(Suppl 1):102-14. Google Scholar21. Sontag S, Robinson M, Roufail W, Berman R, Berlin R, Berger M, et al. Daily omeprazole is needed to maintain healing in erosive esophagitis. A U.S. multicenter double-blind study (Abstract). Am J Gastroenterol. 1992; 87:1258. Google Scholar Author, Article, and Disclosure InformationAuthors: James W. Freston, MD, PhDAffiliations: University of Connecticut Health Center; Farmington, CT 06030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Treatment with Omeprazole for Refractory Reflux Esophagitis: Efficacy and Safety Elly C. Klinkenberg-Knol , Henk P. M. Festen , Jan B. M. J. Jansen , Cornelis B. H. W. Lamers , Frits Nelis , Pleun Snel , Anton Luckers , Cornelius P. M. Dekkers , Niilo Havu , and Stephan G. M. 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