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February 1, 1994The Journal of Experimental MedicineOpen Access

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

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Why the study?

Does oral NG-monomethyl-L-arginine reduce glomerulonephritis and arthritis in MRL-lpr/lpr mice?

Population

MRL-lpr/lpr mice

Comparison

Oral administration of NG-monomethyl-L-arginine vs Normal strains and MRL- and B6-lpr/lpr congenic…

Design

Preclinical

Authors

JWJ. Brice WeinbergThe University of Texas MD Anderson Cancer CenterDGDonald L. GrangerUniversity of UtahDPDavid S. PisetskyUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Should not change clinical practice; hypothesis-generating for nitric oxide synthase inhibition in autoimmune disease.

Structured PICO

Does oral NG-monomethyl-L-arginine reduce glomerulonephritis and arthritis in MRL-lpr/lpr mice?

P
Population
MRL-lpr/lpr mice (model of spontaneous autoimmune disease including inflammatory arthropathy and immune complex glomerulonephritis)
I
Intervention
Oral administration of NG-monomethyl-L-arginine (a nitric oxide synthase inhibitor)
C
Comparator
Normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains (for baseline NO production comparisons); untreated MRL-lpr/lpr mice (implied for intervention)
O
Outcome
Development of glomerulonephritis and intensity of inflammatory arthritissurrogate

Inhibition of nitric oxide synthase with NG-monomethyl-L-arginine prevents glomerulonephritis and reduces inflammatory arthritis in a murine model of autoimmune disease, suggesting NO plays a key role in autoimmune pathogenesis.

Cite This Study

Weinberg et al. (1994) studied this question.

synapsesocial.com/papers/6a77a610d2fa2470761efe4chttps://doi.org/10.1084/jem.179.2.651
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine1992 · 95 citations
  2. 2Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine1991 · 144 citations
  3. 3Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis1991 · 167 citations