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February 1, 2001Arteriosclerosis Thrombosis and Vascular Biology

Vascular Cell Adhesion Molecule-1 Augments Adenovirus-Mediated Gene Transfer

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Population

Stable NIH 3T3 cell lines (VCAM-1(+) and parental VCAM-1(-))

Comparison

Recombinant adenovirus 5 containing the reporter… vs Parental NIH 3T3 cells (VCAM-1(-))

Design

Preclinical

Authors

YCYi ChuRutgers, The State University of New Jersey DHDonald D. HeistadOregon National Primate Research Center MCMyron I. CybulskyGeneral / Preventive / Lipids

Discussion

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Implication

Suggests VCAM-1 targeting for selective gene delivery in atherosclerosis; leaves open translation beyond animal models.

Structured PICO

P

Population

Stable NIH 3T3 cell lines (VCAM-1(+) and parental VCAM-1(-))

I

Intervention

Recombinant adenovirus 5 (Ad5) containing the reporter ss-galactosidase gene

C

Comparator

Parental NIH 3T3 cells (VCAM-1(-))

O

Outcome

Total ss-galactosidase activity and number of transgene-positive cellssurrogate

VCAM-1 can mediate adenovirus binding and infection, which may explain the augmented adenovirus-mediated gene transfer observed in atherosclerotic arteries.

Cite This Study

Chu et al. (2001) studied this question.

synapsesocial.com/papers/6a77a78e137c7dcc81bdf7e6 https://doi.org/10.1161/01.atv.21.2.238

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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

1HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses1997 · 1,208 citations
2The Murine CAR Homolog Is a Receptor for Coxsackie B Viruses and Adenoviruses1998 · 360 citations
3Complexes of Adenovirus with Polycationic Polymers and Cationic Lipids Increase the Efficiency of Gene Transfer in Vitro and in Vivo1997 · 263 citations