Population
A549 cells
Comparison
Treatment with neuraminidase and/or alpha_v… vs Untreated or control-treated A549 cells
Design
Preclinical
Authors
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Sialic acid dependence may guide adenovirus vector design; animal data leave open human translation for gene therapy.
Subgenus D adenoviruses associated with epidemic keratoconjunctivitis (Ad8, Ad19a, Ad37) use sialic acid as a primary functional receptor, which has implications for adenovirus-based gene therapy vectors.
Arnberg et al. (2000) studied this question.
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