May 1, 1999Journal of VirologyOpen Access

The Human HLA-A*0201 Allele, Expressed in Hamster Cells, Is Not a High-Affinity Receptor for Adenovirus Type 5 Fiber

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Population

Hamster cells expressing coxsackie B virus and adenovirus receptor and/or major histocompatibility complex…

Design

Preclinical

Authors

EDElizabeth DavisonGuy's Hospital IKIan KirbyLondon Biofoundry TETim ElliottUniversity of Bristol

Discussion

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Implication

CAR as Ad5 receptor in hamster cells warrants no clinical change; leaves open human validation and vector translation.

Structured PICO

Population

Hamster cells expressing coxsackie B virus and adenovirus receptor (CAR) and/or major histocompatibility complex (MHC) class I allele HLA-A*0201

Intervention

Adenovirus type 5 (Ad5) fiber

Outcome

Binding affinity of Ad5 fiber to the expressed receptorssurrogate

This study demonstrates that CAR, rather than the HLA-A*0201 allele, serves as the high-affinity receptor for Adenovirus type 5 fiber on hamster cells.

Cite This Study

Davison et al. (1999) studied this question.

synapsesocial.com/papers/6a77a78e137c7dcc81bdf7ea https://doi.org/10.1128/jvi.73.5.4513-4517.1999

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The Human HLA-A*0201 Allele, Expressed in Hamster Cells, Is Not a High-Affinity Receptor for Adenovirus Type 5 Fiber

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Human HLA-A*0201 Allele, Expressed in Hamster Cells, Is Not a High-Affinity Receptor for Adenovirus Type 5 Fiber

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider