The human alpha 2 subunit of VLA-2 is identified as a critical receptor for infection by echoviruses 1 and 8.
VLA-2 blockade merits preclinical testing as an echovirus entry inhibitor; leaves open translation to human infection models.
Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.
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Bergelson et al. (1993) studied this question.
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