Key result
Echovirus 1 infection induced a 10-fold increase in immediate-early genes c-jun, junB, and c-fos at 10 hours post-infection, which required viral replication rather than just receptor binding.
Population
Human osteogenic sarcoma (HOS) cell lines (MG-63, HOS, HOS pα2AW)
Comparison
Echovirus 1 (and Echovirus 7) infection vs Uninfected cells, cells treated with antiviral…
Design
Preclinical
Follow-up
10 hours
Authors
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May guide mechanistic studies of enteroviral myocarditis; leaves open human cardiac relevance.
Effect estimate: 10-fold induction
Echovirus 1 replication, rather than merely binding to its VLA-2 receptor, is required for the induction of cellular immediate-early genes.
Huttunen et al. (1997) studied Echovirus 1 infection (in vitro). Echovirus 1 infection vs. Uninfected cells or binding without replication (MG-63 cells or WIN 54954) was evaluated on Induction of immediate-early genes (c-jun, junB, c-fos) (10-fold induction). Echovirus 1 infection induced a 10-fold increase in immediate-early genes c-jun, junB, and c-fos at 10 hours post-infection, which required viral replication rather than just receptor binding.
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