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February 15, 2002Journal of VirologyOpen Access

Internalization of Echovirus 1 in Caveolae

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Population

Host cells (in vitro model) infected with Echovirus 1 (EV1)

Design

Preclinical

Authors

VMVarpu MarjomäkiUniversity of JyväskyläVPVilja PietiäinenUniversity of HelsinkiHMHeli MatilainenMalaghan Institute of Medical Research

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Overview

Supports caveolae-dependent EV1 entry in vitro; leaves open relevance to human infection or antiviral strategies.

Structured PICO

P
Population
Host cells (in vitro model) infected with Echovirus 1 (EV1)
I
Intervention
Echovirus 1 infection and expression of dominant negative caveolin
O
Outcome
Route of EV1 entry into host cells and role of caveolaesurrogate

Echovirus 1 utilizes caveolae for entry into host cells, which is essential for its viral replication cycle.

Cite This Study

Marjomäki et al. (2002) studied this question.

synapsesocial.com/papers/6a87cd750112b7b407bb50d9https://doi.org/10.1128/jvi.76.4.1856-1865.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-21993 · 103 citations
  2. 2RGD-dependent entry of coxsackievirus A9 into host cells and its bypass after cleavage of VP1 protein by intestinal proteases1991 · 153 citations
  3. 3Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment.1992 · 292 citations
  4. 4Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic Tail1999 · 220 citations
  5. 5MHC class I molecules are enriched in caveolae but do not enter with simian virus 40.1998 · 71 citations