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April 1, 2004Proceedings of the National Academy of SciencesOpen Access

Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis

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Why the study?

Does COMP-Ang1 prevent radiation-induced endothelial cell apoptosis and improve survival in irradiated mice?

Population

Male FVB mice, 10-12 weeks old, subjected to whole-body irradiation (12-15 Gy)

Comparison

COMP-Ang1 100 µg administered intravenously in… vs 100 µg of BSA injected intravenously at the same…

Design

Preclinical, Outcome assessors were unaware of the experimental conditions

Follow-up

Survival monitored every 12 h

Authors

CCChung‐Hyun ChoSeoul National UniversityRKRichard A. KammererPaul Scherrer InstituteHLHyuek Jong LeeWellcome Centre for Cell-Matrix Research

Discussion

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Implication

COMP-Ang1 may protect endothelium in irradiated mice; hypothesis-generating for radioprotection in human radiotherapy.

Structured PICO

Does COMP-Ang1 prevent radiation-induced endothelial cell apoptosis and improve survival in irradiated mice?

P
Population
Male FVB mice, 10-12 weeks old, subjected to whole-body irradiation (12-15 Gy)
I
Intervention
COMP-Ang1 100 µg administered intravenously in 33-µg doses at 30 min before, 30 min after, and 90 min after irradiation
C
Comparator
100 µg of BSA injected intravenously at the same time points
O
Outcome
Microvascular endothelial cell apoptosis in intestinal villi and overall survivalhard clinical

COMP-Ang1 protects against radiation-induced microvascular endothelial apoptosis and prolongs survival in mice, suggesting potential as a therapeutic protectant during radiotherapy.

Cite This Study

Cho et al. (2004) studied this question.

synapsesocial.com/papers/6a77ae1fdf493903fd1f1ca9https://doi.org/10.1073/pnas.0307575101
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