Why the study?
Does rotavirus vaccination prevent rotavirus acute gastroenteritis and related hospitalizations in children under 2 years old?
Does rotavirus vaccination prevent rotavirus acute gastroenteritis and related hospitalizations in children under 2 years old?
Rotavirus vaccination demonstrates high effectiveness in preventing acute gastroenteritis and related hospitalizations in Spanish children under 2 years old.
Supports robust real-world protection against acute gastroenteritis in young children; extends trial efficacy to observational settings.
With the aim of determining rotavirus vaccine effectiveness (RVVE) in Spain, from Oct-2008/Jun-2009, 467 consecutive children below 2 years old with acute gastroenteritis (AGE) were recruited using a pediatric research network (ReGALIP-www.regalip.org) that includes primary, emergency and hospital care settings. Of 467 enrolled children, 32.3% were rotavirus positive and 35.0% had received at least one dose of any rotavirus vaccine. RRVE to prevent any episode of rotavirus AGE was 91.5% (95% CI: 83.7%-95.6%). RVVE to prevent hospitalization by rotavirus AGE was 95.6% (85.6-98.6%). No differences in RVVE were found regarding the vaccine used. Rotavirus vaccines have showed an outstanding effectiveness in Spain.
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Martinón‐Torres et al. (2011) studied this question.
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