Why the study?
Does the splanchnic anti-inflammatory pathway, rather than the vagus nerve, act as the efferent arm of the inflammatory reflex in endotoxaemic animal models?
Population
Endotoxaemic animal models
Comparison
Splanchnic anti-inflammatory pathway vs Cholinergic anti-inflammatory pathway
Design
Review
Authors
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Vagus nerves appear uninvolved in endotoxemic inflammatory reflex; leaves open efferent pathway and clinical translation.
Does the splanchnic anti-inflammatory pathway, rather than the vagus nerve, act as the efferent arm of the inflammatory reflex in endotoxaemic animal models?
This review challenges the traditional model of the cholinergic anti-inflammatory pathway, proposing instead that the sympathetic splanchnic nerves form the efferent arm of the inflammatory reflex.
Martelli et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: