Key result
The inflammatory reflex regulates the immune system by inhibiting inflammation via the cholinergic anti-inflammatory pathway.
Why the study?
The inflammatory reflex is a neurophysiological mechanism regulating the immune system, but its detailed physiology and components require comprehensive review.
This review summarizes the anatomic and physiologic components of the inflammatory reflex, a neurophysiological mechanism regulating the immune system via the cholinergic anti-inflammatory pathway.
The inflammatory reflex is a neurophysiological mechanism that regulates the immune system. The efferent branch of the reflex the cholinergic anti-inflammatory pathway, which inhibits inflammation by suppressing cytokine synthesis via release of acetylcholine in organs of the reticuloendothelial system, including the spleen, liver, and gastrointestinal tract. Acetylcholine binds to alpha7 nicotinic acetylcholine receptors expressed by macrophages and other cytokine-producing cells. Receptor-ligand engagement suppresses proinflammatory cytokines and prevents tissue damage. Herein is a review of some of the experimental studies that define the inflammatory reflex and its anatomic and physiologic components.
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Oke et al. (2007) conducted a review in Inflammation. Inflammatory reflex was evaluated. The inflammatory reflex is a neurophysiological mechanism that regulates the immune system by inhibiting inflammation through the cholinergic anti-inflammatory pathway.
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