September 1, 1980Journal of Trauma and Acute Care Surgery

Effects of Blunt Cardiac Trauma on Coronary Vasomotion, Perfusion, Myocardial Mechanics, and Metabolism

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Population

24 open-chest, working swine hearts with controlled perfusion of the left anterior descending coronary artery

Comparison

Single impact involving the LAD artery vs Baseline (before impact)

Design

Preclinical

Follow-up

1 hour

Authors

ALA. J. LiedtkeUniversity Hospital of Basel RARobert AllenDayStar (United States)SNS. H. NellisPennsylvania State University

Discussion

Member takes

Implication

Acute coronary flow changes after blunt impact in animals warrant caution extrapolating to patients; leaves open human mechanistic studies.

Structured PICO

Population

24 open-chest, working swine hearts with controlled perfusion of the left anterior descending (LAD) coronary artery

Intervention

Single impact involving the LAD artery (blunt cardiac trauma)

Comparator

Baseline (before impact)

Outcome

Changes in proximal and distal coronary vascular resistance (CVR), small-vessel perfusion, regional and global mechanical function, and metabolism (myocardial oxygen consumption and lactate extraction)surrogate

Blunt cardiac trauma induces significant changes in vasomotor tone and perfusion distributions, providing a physiological basis for trauma-related hemodynamic and electrocardiographic abnormalities.

Cite This Study

Liedtke et al. (1980) studied this question.

synapsesocial.com/papers/6a77b60cd8eb58afc2be1100 https://doi.org/10.1097/00005373-198009000-00012

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Implication

Acute coronary flow changes after blunt impact in animals warrant caution extrapolating to patients; leaves open human mechanistic studies.