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December 1, 2025Clinical Interventions in AgingOpen Access

Patterns and Factors of Intrinsic Capacity Impairment in Older Adults with Chronic Diseases: A Latent Class Analysis

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Why the study?

Older adults frequently experience intrinsic capacity decline before serious illness, but the patterns of impairment and their influencing factors in those with chronic diseases needed exploration.

Population

8427 older adults (≥ 60 years) with chronic diseases in Zunyi City, China

Design

Cross-sectional study using latent class analysis

Authors

YZYumeng ZhangZJZhixia JiangRHRujun Hu

Discussion

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Overview

Supports pattern-based IC assessment in chronic disease; leaves open whether targeting specific classes improves outcomes.

Structured PICO

P
Population
8,427 older adults (≥ 60 years) with chronic diseases in Zunyi City, China, mean age 71.69, 50.85% male. Key exclusion criteria: acute critical illness (shock, respiratory failure, acute heart failure, acute myocardial infarction, stroke) or acute exacerbation/advanced stage of chronic disease with expected survival <3 months.
O
Outcome
Patterns of intrinsic capacity (IC) impairment and their influencing factorscomposite

Intrinsic capacity impairment is highly prevalent (87.56%) and heterogeneous among older adults with chronic diseases, highlighting the need for targeted early interventions based on specific impairment patterns.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/6a77b6caa0847c3df1ec9734https://doi.org/10.2147/cia.s549998
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors associated with intrinsic capacity impairment in hospitalized older adults: a latent class analysis2024 · 18 citations
  2. 2Heterogeneity of intrinsic capacity and associations with adverse health outcomes in China: a large community-based cross-sectional study2026
  3. 3Intrinsic capacity loss rates and protective factors among individuals aged 80 years and older in Chinese nursing homes: A latent class analysis2024 · 9 citations
  4. 4Cumulative effect of intrinsic capacity domains on geriatric syndromes and functionality in older inpatients2025 · 5 citations
  5. 5Cumulative effect of intrinsic capacity domains on geriatric syndromes and functionality in older inpatients2025