Why the study?
Does supplemental O2 modulate ATP production during exercise in hypoxemic COPD patients?
Population
20 subjects total: 6 chronic obstructive pulmonary disease patients with severe hypoxemia, 7 COPD patients…
Comparison
Supplemental O2 during exercise. vs Room air during identical exercise.
Design
Other
Authors
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Supports O2 to favor oxidative ATP production in hypoxemic COPD exercise; hypothesis-generating and should not yet change practice.
Does supplemental O2 modulate ATP production during exercise in hypoxemic COPD patients?
In severely hypoxemic COPD patients, oxygen availability limits intramuscular oxidative metabolism during exercise, as acute hypoxemia increases anaerobic and decreases aerobic ATP production.
Mannix et al. (1995) studied this question.
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