Why the study?
RNA structure is closely related to function in the viral replication cycle, making technological progress and new developments in high-throughput RNA structure analysis very important.
Understanding viral RNA structure-function relationships is crucial for developing new antiviral therapeutics.
Highlights viral RNA motifs for replication studies; leaves open targeted antiviral applications in cardiovascular disease.
The relationship between conserved structural motifs and their biological function in the virus replication cycle is the interest of many researchers around the world. RNA structure is closely related to RNA function. Therefore, technological progress in high-throughput approaches for RNA structure analysis and the development of new ones are very important. In this mini review, we discuss a few perspectives on the structural elements of viral genomes and some methods used for RNA structure prediction and characterization. Based on the recent literature, we describe several examples of studies concerning the viral genomes, especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV). Herein, we emphasize that a better understanding of viral genome architecture allows for the discovery of the structure-function relationship, and as a result, the discovery of new potential antiviral therapeutics.
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Nalewaj et al. (2022) studied this question.
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