Intermedin1–53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase

Rats with cardiac hypertrophy induced by abdominal aortic constriction (AAC) and cultured cardiomyocytes

Intermedin1-53 (IMD1-53) 100 ng/kg/h administered systemically via mini-osmotic pump for 4 weeks

Untreated AAC rats and pretreatment with compound C (AMPK inhibitor)

Cardiac hypertrophy (measured by heart weight to body weight ratio, haemodynamics, echocardiography, histological analyses, and expression of ANP and BNP)surrogate