January 1, 1997Circulation Research
Angiotensin II Stimulates c-Jun NH2-Terminal Kinase in Cultured Cardiac Myocytes of Neonatal Rats
Population
Cultured cardiac myocytes of neonatal rats
Comparison
Angiotensin II at doses ranging from 10 to 10… vs Unstimulated cardiac myocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May link Ang II to myocyte hypertrophy signaling; leaves open in vivo relevance and therapeutic targeting.
Structured PICO
P
Population
Cultured cardiac myocytes of neonatal rats
I
Intervention
Angiotensin II (Ang II) at doses ranging from 10(-9) to 10(-6) mol/L
C
Comparator
Unstimulated cardiac myocytes
O
Outcome
Activation of c-Jun NH2-terminal kinase (JNK)surrogate
Angiotensin II activates JNK in cultured neonatal rat cardiac myocytes via the AT1 receptor, intracellular Ca2+, and protein kinase C, suggesting a mechanism for gene expression regulation during cardiac hypertrophy.
Cite This Study
Kudoh et al. (1997) studied this question.