Angiotensin II rapidly induces the proto-oncogene c-jun and activates the AP-1 enhancer element in rat aortic smooth muscle cells, providing a molecular mechanism for its growth-promoting effects in the vascular wall.
May explain Ang II-driven vascular growth; hypothesis-generating in animal cells, no practice change.
Angiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-jun and, in addition, could activate the AP-1 enhancer element. These data add support for a role of Ang II as an important mediator of vascular smooth muscle cell growth.
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Naftilan et al. (1990) studied this question.
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