Key result
Angiotensins II and III directly induced cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells, effects which were inhibited by the AT1 receptor antagonist losartan.
Population
Cultured arterial smooth muscle cells
Design
Preclinical
Authors
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Supports AT1-mediated hypertrophy in vitro; leaves open relevance to human vascular remodeling.
Angiotensin II and III directly induce arterial smooth muscle cell hypertrophy and c-fos expression via the AT1 receptor, while angiotensin I acts indirectly.
Millet et al. (1992) studied Cultured arterial smooth muscle cells. Angiotensins (I, II, III) was evaluated on Cell size, protein content, and c-fos expression. Angiotensins II and III directly induced cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells, effects which were inhibited by the AT1 receptor antagonist losartan.
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