Key result
Endothelin-1 and angiotensin II induced a 20-25-fold rise in Egr-1 and a 10-20-fold rise in c-fos messenger RNA within 15 minutes in isolated adult rat cardiomyocytes.
Population
Isolated adult rat cardiomyocytes from male Wistar-Kyoto rats
Design
Preclinical
Follow-up
15 min
Authors
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These rapid gene responses in rat cells leave open hypertrophic pathway relevance to human myocardium; further studies needed.
Effect estimate: 20-25-fold rise in Egr-1; 10-20-fold rise in c-fos
Angiotensin II and endothelin-1 induce immediate-early genes Egr-1 and c-fos in adult rat cardiomyocytes, suggesting a role in the signal transduction pathway for myocardial hypertrophy.
Neyses et al. (1993) studied Myocardial hypertrophy. Angiotensin II and endothelin-1 was evaluated on Induction of Egr-1 and c-fos messenger RNA (20-25-fold rise in Egr-1; 10-20-fold rise in c-fos). Endothelin-1 and angiotensin II induced a 20-25-fold rise in Egr-1 and a 10-20-fold rise in c-fos messenger RNA within 15 minutes in isolated adult rat cardiomyocytes.
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